Structure, function and regulation of the vacuolar (H+)-ATPases
نویسندگان
چکیده
منابع مشابه
Structure and properties of the vacuolar (H+)-ATPases.
Function of V-ATPases The vacuolar (H)-ATPases (or V-ATPases) are a family of ATPdependent proton pumps that are responsible for acidification of intracellular compartments in eukaryotic cells (1–3). Acidification of vacuolar compartments plays an important role in a variety of cellular processes, particularly membrane traffic processes. In receptor-mediated endocytosis, acidification of endoso...
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متن کاملRegulation of membrane-type 1 matrix metalloproteinase activity by vacuolar H+-ATPases.
Membrane-type 1 matrix metalloproteinase (MT1-MMP) is a key enzyme in normal development and malignant processes. The regulation of MT1-MMP activity on the cell surface is a complex process involving autocatalytic processing, tissue inhibitor of MMPs (TIMP) binding and constitutive internalization. However, the fate of internalized MT1-MMP is not known. Acidification of intracellular vacuolar c...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1998
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(98)01425-2